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致死量标准差是表示化学品毒性的指标,其大小可以用剂量死亡曲线的坡度度量.该文指出毒力回归方程的b值不能用于表示剂量死亡曲线的坡度,及表示急性毒作用,1/b也不能作为试验精密度指数.应该用S值度量剂量死亡曲线的坡度.S值也是致死量的标准差.S值还可以作为急性毒作用带指标及试验精密度指数.对于概率单位回归LD50计算法,S值计算公式为S=log-1(1/b).“,”The standard deviation of lethal dose is an important acute toxicity parameter of a chemical substance as LD50 and can be measured by the slope of the dose/lethal curve. This paper indicated that the slope can not be measured by the acute toxicity action zone, and the 1/b can not be the precision indez of the test too. The slope of dose/lethal curve can be measured by the S value. S value is the standard deviation of lethal dose. S value is calculated with the formula S = log-1 (1/b). The relationship between S and MNLD of a chemical substance is discussed.