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有研究表明 ,Ｃａ2 + 是细胞凋亡中一个重要的信使 ,钙通道拮抗剂 (ＣＣＢ)可通过抑制钙内流 ,从而抑制细胞凋亡[1 ] 。但也有研究表明 ,ＣＣＢ能增强某些实体瘤的化疗效果[2 ] 。有学者将ＣＣＢ———维拉帕米 (异搏定 )作为耐药逆转剂用于难治性白血病的治疗 ,其作用机制不甚
Studies have shown that Ca2 + is an important messenger in apoptosis, calcium channel blockers (CCB) can inhibit apoptosis by inhibiting calcium influx [1]. However, some studies have shown that CCB can enhance the chemotherapy effect of some solid tumors [2]. Some scholars have CCB --- Verapamil (Verapamil) as a drug resistance reversal agent for the treatment of refractory leukemia, its mechanism is not very effective