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老年豚鼠喂饲高脂膳食形成老年高脂血症模型,然后再灌服具补肾化痰祛瘀作用的中药复方浓缩液4周。结果为造模后血中SOD活性、RBC-C_3bR花环率降低,血清LPO、CIC含量及RBC-IC花环率升高,与造模前及对照组比较,均具显著性差异。经服药后,SOD活性恢复,RBC-C_3bR花环率升高,LPO、CIC含量及RBC-IC花环率降低,与造模后比较,差异十分显著(P<0.005～0.001)。对SOD、LPO、CIC与RCIA功能的相关性研究表明,SOD活性与RBC-C_3bR花环率呈正相关,与RBC-IC花环率呈负相关;LPO、CIC含量则与之相反,并均具统计学意义。作者经分析认为老年高脂血症出现的上述变化均和自由基有关,且它们相互影响,互为因果,为导致AS及CHD的重要原因之一。提示该中药复方有预防和减轻高脂血症诱发AS、CHD的作用。
Old guinea pigs were fed a high-fat diet to form a model of senile hyperlipidemia, and then the Chinese herbal compound concentrate with a role in tonifying and resolving kidney phlegm was irrigated for 4 weeks. As a result, SOD activity in blood, RBC-C_3bR rosette rate, serum LPO, CIC content, and rosette rate of RBC-IC rose after modeling, and there was a significant difference compared with the pre-model and control groups. After administration, SOD activity was restored, RBC-C_3bR rosette rate, LPO, CIC content and RBC-IC rosette rate decreased, compared with the model after the difference is very significant (P <0.005 ~ 0.001). The correlation study of SOD, LPO, CIC and RCIA functions showed that SOD activity was positively correlated with RBC-C_3bR rosette rate, negatively correlated with RBC-IC rosette rate; LPO and CIC content were opposite, and both had statistical significance. The authors analyzed that the above changes in the appearance of hyperlipidemia in the elderly are all related to free radicals, and that they affect each other and cause and cause each other, which is one of the important causes of AS and CHD. It is suggested that the Chinese herbal compound can prevent and reduce hyperlipidemia induced AS and CHD.