近年来随着骨髓、器官移植的广泛开展,导管技术,放化疗的广泛应用以及广谱抗生素的使用,真菌感染逐年增加。马尔尼菲青霉菌(penicillium marneffe,PM)是极少数能使人致病的青霉菌之一,由该菌引起的感染常发生于免疫缺陷的患者。1988年以来,随着全球艾滋病(HIV)的流行,该机会致病菌感染的发病率逐年增高〔1〕。在我国HIV合并PM的报道多见于南方地区,如香港、广州、广 In recent years, with the extensive development of bone marrow and organ transplantation, extensive use of catheterization and radiotherapy and chemotherapy, and the use of broad-spectrum antibiotics, fungal infections have been increasing year by year. Penicillium marneffe (PM) is one of the very few penicillin-causing pathogens. Infections caused by this bacterium often occur in immunodeficient patients. Since 1988, with the global AIDS epidemic (HIV), the incidence of opportunistic infections increased year by year 〔1〕. In our country HIV merger PM more common in the southern region, such as Hong Kong, Guangzhou, Canton