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普萘洛尔在中国处方的剂量较在美国和欧洲所广泛使用的剂量低。大多数有关药物效应的研究均未涉及研究对象的人种或种族间的背景,中国人对低剂量有效,可能由于人体对药物的处置不同,导致较高的血药浓度;或由于病人对药物敏感性的不同,引起相同的血药浓度而效应不同。本文旨在研究药物动力学及药效学诸因素,决定能否用β受体本身的变化来解释心脏敏感性改变。
Propranolol is prescribed at lower doses in China than is widely used in the United States and Europe. Most studies on drug effects did not address the racial or ethnic background of subjects. Chinese were effective at low doses, possibly resulting from higher levels of plasma concentrations due to the different human body’s handling of drugs, Different sensitivity, causing the same blood concentration and the effect is different. This article aims to study the pharmacokinetics and pharmacodynamics of various factors, to determine whether changes in the beta receptor itself to explain changes in cardiac sensitivity.