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用阳离子化牛血清白蛋白造成家兔原位免疫复合物肾炎,观察保肾甲丸的疗效和探讨其治疗机理。实验结果表明,服药组尿素氮和血肌酐治疗前后的差值与对照组相比有明显异性(P<0.05),服药组肾小球渗出率、新月体形成率等都明显低于对照组。作者认为保肾甲丸既对肾功能有保护作用又对肾炎病理有明显修复作用,其治疗机理可能与维护肾元气、调整机体免疫有关。
Cationic bovine serum albumin (BSA) was used to induce in situ immune complex nephritis in rabbits. The efficacy of Baoshenjia pill was observed and its therapeutic mechanism was explored. The experimental results showed that the differences between the medication group before and after the treatment of urea nitrogen and serum creatinine were significantly different from those in the control group (P<0.05). The glomerular exudation rate and the rate of crescent formation were significantly lower in the medication group than in the control group. group. The author believes that Baoshenjiawan has both protective effects on renal function and obvious repair of nephritis pathology, and its therapeutic mechanism may be related to maintenance of kidney qi and adjustment of body immunity.