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目的观察川芎嗪对脑挫伤大鼠脑组织中丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)含量及脑组织含水量的影响,探讨川芎嗪在治疗脑挫伤中的应用。方法建立自由落体大鼠脑挫伤模型,治疗组脑挫伤后第2天开始应用川芎嗪腹腔注射治疗,对照组腹腔注射等量生理盐水,连续应用6d。正常组不致伤。检测治疗组、对照组及正常组大鼠脑组织中MDA、SOD、NO含量及脑组织含水量,并进行统计分析。结果脑挫伤后大鼠脑组织中MDA、NO含量及脑组织含水量较正常组增高,SOD含量较正常组降低(P<0.05)。川芎嗪治疗组大鼠脑组织中MDA、NO含量及脑组织含水量较对照组显著降低,SOD含量较对照组显著上升(P<0.05)。结论川芎嗪能够有效提高挫伤后脑组织中SOD含量,减少MDA及NO含量产生,有效改善脑水肿,从而发挥治疗作用。
Objective To observe the effects of ligustrazine on malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO) content and brain tissue water content in brain tissue of rats with brain contusion, and to explore the effects of tetramethylpyrazine in the treatment of brain contusion. Application. Methods The brain injury model of free-fall rats was established. The treatment group received intraperitoneal injection of ligustrazine on the second day after cerebral contusion. The control group received intraperitoneal injection of normal saline for 6 days. The normal group will not be injured. The content of MDA, SOD, NO and brain tissue water content in brain tissue of rats in the treatment group, control group and normal group were detected, and statistical analysis was performed. Results The contents of MDA, NO and brain water content in brain tissue of rats after brain contusion were higher than those in normal group, and SOD content was lower than that in normal group (P<0.05). The contents of MDA, NO and water content in brain tissue of the rats in the Ligustrazine-treated group were significantly lower than those in the control group, and the SOD content was significantly higher than that in the control group (P<0.05). [Conclusion] Tetramethylpyrazine can effectively increase the content of SOD in the brain tissues after contusion, reduce the production of MDA and NO, and effectively improve cerebral edema, thus exerting therapeutic effects.