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目的以FOLFOX4方案为基础,改变奥沙利铂、5-氟脲嘧啶和亚叶酸钙的使用方法及剂量,设计改良的FOLFOX方案,一线治疗晚期大肠癌,观察其疗效和毒副反应。方法51例晚期大肠癌患者接受奥沙利铂85mg/m2静脉点滴2h,第1天;亚叶酸钙400mg/m2静脉点滴2h,第1天;5-氟脲嘧啶2.6g/m2,持续静脉输注46h,每2周重复。结果完全缓解2例、部分缓解22例、稳定14例、疾病进展13例,全组有效率47.0%(24/51)。生活质量明显改善38例(74.6%)。毒副反应主要是恶心呕吐、骨髓抑制、手足麻木,程度均较轻。结论改良FOLFOX方案一线治疗晚期大肠癌疗效确切,毒副反应可耐受。
OBJECTIVE To modify the use and dosage of oxaliplatin, 5-fluorouracil and leucovorin based on the FOLFOX4 regimen, to design a modified FOLFOX regimen and to treat advanced colorectal cancer in the first-line treatment. The curative effect and toxicity were observed. Methods Fifty-one patients with advanced colorectal cancer received intravenous infusion of oxaliplatin 85mg / m2 for 2 hours on the first day, leucovorin 400mg / m2 intravenously for 2 hours on the first day, and 5-fluorouracil 2.6g / m2 for continuous intravenous infusion Note 46h, repeated every 2 weeks. The results of complete remission in 2 cases, partial remission in 22 cases, stable in 14 cases, disease progression in 13 cases, the effective rate was 47.0% (24/51). The quality of life improved significantly in 38 cases (74.6%). Toxic and side effects are mainly nausea and vomiting, bone marrow suppression, numbness of hands and feet, both to a lesser extent. Conclusion The modified FOLFOX regimen is effective in treating advanced colorectal cancer in the first-line treatment, and its side effects are tolerable.