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2-[2-(4-二甲氨基苯基)乙烯基]-1-甲基碘化吡啶(1)具有减慢心率等生理活性,是一种潜在的钙拮抗剂。本文以(1)和稀土钨杂多酸钠(2)为原料合为原料合成了15种新的配合物(3),对其结构(图1)和性质进行了表征。药理试验结果表明3对小白鼠心脏的作用与1相似但作用较强。
2- [2- (4-dimethylaminophenyl) ethenyl] -1-methylpyridinium iodide (1) is a potential calcium antagonist with physiological activity such as heart rate reduction. In this paper, 15 new complexes (3) were synthesized from (1) and sodium tungstophosphate (2) as raw materials, and their structures (Fig. 1) and their properties were characterized. Pharmacological test results show that 3 on the role of the mouse heart and 1 similar but strong role.