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质量比为70∶30的n-HA/CS复合材料与适量ZnO粉末的共混物为固相,选用合适的固化液,按照适当的固/液比例进行调和,制备出一种在空气、生理盐水及血液或体液中均可快速固化的新型n-HA/CS复合骨水泥,考查了ZnO含量对该骨水泥理化性能的影响。结果表明:当ZnO与复合材料质量比为1∶8、固化液与固相粉末比例(L/P)为1.2ml/g时,所制备的复合骨水泥抗压强度和固化时间均较佳,能够满足临床操作的需要。ZnO/复合材料质量比分别为1∶8和1∶5的骨水泥在生理盐水中的pH值随浸泡时间的延长而逐渐升高,前者在第20d时pH值维持在7.28左右,而后者在第20d时的pH值接近7.40,均与人体的pH环境相近。当ZnO/复合材料质量比为1∶8时,骨水泥对水的接触角最小,表明其具有良好的润湿性能。ZnO含量越高,骨水泥的吸水率越低,这对于保持骨水泥植入体内后的体积稳定性具有重要价值。SEM观察发现,固化后的骨水泥中含有大量微孔,有利于营养物质的传递及代谢废物的排泄,并利于新生骨组织的长入及爬行替代。
The blend of n-HA / CS composite with an appropriate amount of ZnO powder at a mass ratio of 70:30 is a solid phase, and a suitable solidification liquid is used to reconcile with a suitable solid / liquid ratio to prepare a blend of air, Saline and fast solidified n-HA / CS composite bone cement in blood or body fluid, and investigated the effect of ZnO content on the physicochemical properties of the bone cement. The results show that the compressive strength and curing time of the composite bone cement are better when the mass ratio of ZnO to the composite material is 1: 8, and the ratio of solidified liquid to solid phase powder (L / P) is 1.2ml / g. To meet the needs of clinical practice. The pH value of bone cement with the mass ratio of ZnO / composites of 1: 8 and 1: 5 in physiological saline gradually increased with the soaking time, the former maintained at about pH 7.28 on the 20th day, The pH of the 20th day was close to 7.40, both with the human body’s pH environment similar. When the mass ratio of ZnO / composite material is 1: 8, the contact angle of cement with water is the smallest, indicating that it has good wettability. The higher the ZnO content, the lower the water absorption of the bone cement, which is of great value for maintaining the volume stability of the bone cement after implantation. SEM observation found that the cured bone cement contains a large number of micropores, which is conducive to the transfer of nutrients and excretion of metabolic waste, and is conducive to the growth of new bone tissue and crawling alternative.