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肺小动脉和小静脉壁上普遍存在肾上腺素能α和β受体,因此在研究缺氧性肺动脉高压形成机制这一问题时,人们对交感神经介质及共受体的作用非常重视。Poricelli和Bergofsky在灌流猫的去神经左下肺时发现β受体阻断剂能加强缺氧引起的肺血管收缩。但在慢性缺氧实验中却得到不同结果,OStadal(1980)报道β受体阻断剂(Trime-pranol)对大鼠缺氧性右心室高压和右心室肥厚具有明显的保护作用。Vaelkel(1982)报道心得安能抑制大鼠缺氧性右室肥厚。Dennis(1982)的实验结果证明接受心得安治疗的减压缺氧动物,共右心室肥厚程度与非治疗组相同。本实验目的在于探讨β受体阻断剂心得安对慢性问断低压缺氧引起的大鼠右心室高压和心室肥厚是否具有保护作用?
The adrenergic alpha and beta receptors are commonly found in the walls of the pulmonary arterioles and venules. Therefore, the role of the sympathetic mediators and co-receptors in the study of the pathogenesis of hypoxic pulmonary hypertension is of great importance. Poricelli and Bergofsky found that β-blockers enhance hypoxia-induced pulmonary vasoconstriction during perfusion of the cat’s denervated left lower lung. However, different results were obtained in chronic hypoxia experiments. OStadal (1980) reported that Trime-pranol has a significant protective effect on hypoxic right ventricular hypertrophy and right ventricular hypertrophy in rats. Vaelkel (1982) reported that propranolol can inhibit hypoxic right ventricular hypertrophy in rats. The experimental results of Dennis (1982) demonstrated that the depressive and anoxic animals receiving propranolol had the same degree of right ventricular hypertrophy as the non-treated group. The purpose of this experiment is to investigate whether β-blocker propranolol has protective effects on chronic right ventricular hypertrophy and ventricular hypertrophy induced by chronic hypobaric hypoxia in rats.