本文系统地小结了本实验室近三年来关于心钠素与肺水肿的研究工作。应用免疫组织化学、放射免疫测定、液相层析和分子杂交技术证明肺内可以产生和分泌心钠素。它除了能利钠、利尿、舒张血管和气管外,还有增加肺表面活性物质的作用。 应用放射受体分析法证明,肺内亦具有特异性心钠素受体存在,它可以通过激活颗粒性乌苷酸环化酶使cGMP增加,发挥其生理作用,肺内cGMP的变 This article systematically summarizes the laboratory nearly three years on atrial natriuretic peptide and pulmonary edema research work. Application of immunohistochemistry, radioimmunoassay, liquid chromatography and molecular hybridization technology to prove that the lung can produce and secrete atrial natriuretic peptide. In addition to its sodium, diuretic, vasodilators and trachea, it also increases the role of pulmonary surfactant. Radioreceptor analysis proved that the lung also has a specific presence of atrial natriuretic peptide receptors, which can activate cGMP by increasing the activity of granulosin, which exerts its physiological effects. The cGMP in the lung changes