探讨妊娠合并癫痫患者抗病药物浓度的变化，前瞻性研究了４１例妊娠合并癫痫患者。用ＨＰＬＣ方法或ＴＤＸ仪器测定血浓度。结果妊娠期间１９例（４６％）患者发作频率增加，１７例（４２％）患者无发作，５例（１２％）患者发作频率同妊娠前。妊娠期抗痫药血浓度较妊娠前低。作者认为：对多年无发作者，妊娠前即停用抗痫药，活动性癫痫患者勿停止治疗。改变药物剂量不仅根据药物浓度，还要考虑发作频率，药物对胎儿的副作用等。 To investigate the changes of disease-resistant drug concentration in patients with pregnancy complicated with epilepsy, and prospectively study 41 patients with pregnancy complicated with epilepsy. Blood concentration was determined by HPLC method or TDX instrument. RESULTS: Nineteen (46%) patients had an increased seizure frequency during pregnancy, 17 (42%) had no seizures and five (12%) had seizures at the same frequency as before gestation. Pregnancy antiepileptic serum concentrations lower than before pregnancy. The authors believe that: for many years without the author, before stopping the use of anti-epileptic drugs, patients with active epilepsy do not stop treatment. Changes in drug dose not only based on drug concentration, but also consider the frequency of seizures, the side effects of drugs on the fetus and so on.