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血清免疫球蛋白(ISG)对预防非甲非乙型肝炎的效果尚未肯定。作者报道用ISG预防非甲非乙型肝炎,其依据是非甲非乙型肝炎为全球性疾病,市售ISG制品可能含有抗非甲非乙型病毒抗体,在病毒入侵期使用ISG则可以减少病毒感染的危险性。291例病人均为接受心脏手术和输血者。所有病人均无肝炎证据,6个月内无黄疸病人接触史和未使用血制品、没有使用肝毒药品。无酗酒。临床检查无肝病体征。143例患者术前24小时和术后1周分别肌肉注射16%的ISG 10ml,对照组148例未注射ISG。所有受试者输血前和手术后2～4周分别采血,以后每月1次至少6月。如谷丙转氨酶升高,则进一步检测HBsAg、抗-HBs和抗-HBc、抗-HAV、ALT和门冬氨酸转移酶(AST)、直接和总胆红素。如病人有肝炎症状,则测定抗-HBc IgM和抗-HAV
The effect of serum immunoglobulin (ISG) on the prevention of non-A, non-B hepatitis is yet to be confirmed. The authors report that ISG prophylaxis of non-A, non-B hepatitis is based on the fact that non-A, non-B, hepatitis B is a global disease and that commercially available ISG preparations may contain anti-A, non-B, and ISG during virus invasion The risk of infection. All 291 patients underwent cardiac surgery and blood transfusion. All patients had no evidence of hepatitis, no history of jaundice within 6 months and no blood products, no hepatotoxic drugs. No alcoholism. Clinical examination without signs of liver disease. 143 patients were intramuscularly injected with 16% ISG 10ml 24 hours before surgery and one week after surgery, respectively. 148 cases in the control group were not injected with ISG. Blood samples were obtained from all subjects before transfusion and from 2 to 4 weeks after surgery, at least once every month for at least 6 months. If elevated alanine aminotransferase, then further detection of HBsAg, anti-HBs and anti-HBc, anti-HAV, ALT and aspartate aminotransferase (AST), direct and total bilirubin. If the patient has hepatitis symptoms, anti-HBc IgM and anti-HAV are tested