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成人呼吸窘迫综合征(ARDS)患者在急性期有严重低氧血症而预后严重,存活者虽可能没有肺功能不全,但伴持续肺功能异常。作者等对 ARDS 经抢救存活的患者进行肺功能,包括运动时无效腔/潮气量(V_D/V_T)、动脉血氧分压(PaO_2)和肺泡-动脉氧分压差(△AaPO_2)的测定。对象选自1975年呼吸监护中心经治的46例 ARDS中的19例存话者,其中资料较齐全者13例。男6例,女7例,年龄15～62岁(平均30岁),除1例既往曾有肺炎外,余均无心肺疾患史。10例不吸烟。治疗过程中均曾使用呼气末正压呼吸。目前无症状,体检未发现慢性呼吸道疾患或肺动脉高压的体征,胸部 X 线均已恢复正常。肺功能检查包括用力肺活量(FVC)、第1秒用力呼气量(FEV_1)、用力呼气流速(FEF)_(25-75)%、肺总量(TLC)、一氧化碳弥散量(D_(L∞))。D_(L∞)正常值取自本实验室同期245名健康非吸烟者。
Patients with adult respiratory distress syndrome (ARDS) have severe hypoxemia in the acute phase with a severe prognosis, although survivors may not have pulmonary insufficiency, but with persistent pulmonary dysfunction. The authors performed pulmonary function tests in patients rescued by ARDS, including V_D / V_T, PaO_2, and △ AaPO_2 during exercise. The subjects were selected from among 19 cases of ARDS in 46 cases of ARDS managed by the Respiratory Care Center in 1975, of which 13 were more complete. 6 males and 7 females, aged 15 to 62 years (mean 30 years). Except for one case of pneumonia, none had a history of heart and lung disease. 10 cases did not smoke. During the treatment have used positive end expiratory pressure breathing. Currently asymptomatic, physical examination did not find signs of chronic respiratory disease or pulmonary hypertension, chest X-ray have returned to normal. Pulmonary function tests included forced vital capacity (FVC), forced expiratory volume in 1 second (FEV_1), forced expiratory flow (FEF) _ (25-75)%, total lung volume (TLC), and carbon monoxide dispersion ∞)). The normal value of D_ (L∞) was taken from 245 healthy non-smokers in our laboratory.