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本文综述了不同细胞周期素的分子结构和对细胞周期的调控作用。在细胞周期的不同时期,周期素与P34~(cdc2)及其相关激酶相作用,产生特定的激酶活性,使细胞通过细胞周期特定的调控点。周期素的累积与降解对细胞周期进程的调控起着重要的作用。
This review summarizes the molecular structure of different cyclin and its regulation of cell cycle. At different stages of the cell cycle, cyclin interacts with P34 cdc2 and its related kinases to produce specific kinase activity that allows cells to pass specific cell cycle control points. The accumulation and degradation of cyclin plays an important role in the regulation of cell cycle progression.