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目的探讨内斜视性弱视患者,在不同视野黑白棋盘格翻转刺激条件下,大脑皮层活动脑磁图的变化。方法单眼内斜视性弱视患者4名,分别进行双眼、单眼全视野刺激,单眼颞侧以及鼻侧视野刺激,记录视觉诱发磁场成份之一的M100的振幅、潜伏期以及源定位的变化情况,与4名正常对照组进行比较。结果双眼全视野刺激,内斜视性弱视组大脑皮层反应M100的振幅降低、潜伏期延长(P<0.05);弱视眼鼻侧视网膜M100的振幅比颞侧视网膜M100的振幅降低、潜伏期延长(P<0.05);非弱视眼M100的振幅比正常对照组M100的振幅降低,潜伏期延长(P<0.05);内斜视性弱视组弱视眼全视野刺激源定位的X轴与正常组比较更偏向原点(P<0.05)。结论内斜视性弱视眼的鼻侧网膜存在一定程度和一定范围的抑制,源定位上弱视眼存在眼优势柱的偏移,斜视性弱视的非弱视眼与正常组也存在功能的差异。
Objective To investigate the changes of cerebral cortex magnetoencephalography in patients with esotropia and amblyopia under the condition of reversal of black and white checkerboard in different fields. Methods Four patients with monocular strabismus amblyopia were stimulated with binocular and monocular panoptophism, monocular temporal and nasal visual field respectively. The amplitude, latency and source localization of M100, one of the components of visual evoked field, were recorded. Normal control group for comparison. Results The amplitude of M100 decreased and the latency prolonged (P <0.05). The amplitude of M100 in nasal retina of amblyopic eyes was lower than that of temporal retina M100 (P <0.05) (P <0.05). The amplitude of M100 in non-amblyopic eyes was lower than that in normal control group (P <0.05). The amplitude of M100 amplitude in the non-amblyopic eyes was more than that in the normal group (P <0.05) . Conclusions There is a certain degree of inhibition of the nasal omentum in esotropia amblyopia and there is a functional difference between the non-amblyopic eye and the normal group in amblyopia.