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目的:检测乳腺癌组织c-met和HER-2表达状况,分析c-met和HER-2表达的相关性,以及c-met和HER-2表达与临床病理及相关分子生物学信息的相关性。方法:回顾性分析临沂市人民医院2005-06-10-2012-02-20乳腺癌患者临床和病理资料106例,采用免疫组织化学染色方法测定c-met及HER-2基因表达,分析c-met与HER-2表达相关性及其与各临床病理指标的相关性。结果:106例乳腺癌患者中,c-met阳性表达率为64.15%(68/106),HER-2为50.94%(54/106),ER为59.43%(63/106),PR为50.00%(53/106)。HER-2基因表达与乳腺癌患者腋窝淋巴结转移(P=0.001)和肿瘤临床分期(P<0.001)相关;c-met基因表达与乳腺癌患者腋窝淋巴结转移(P=0.004)及肿瘤临床分期(P=0.001)相关。两者表达与肿瘤直径以及ER和PR表达差异无统计学意义。HER-2与c-met表达之间无相关性,r=0.071,P=0.172。结论:联合检测c-met及HER-2基因对乳腺癌的淋巴结转移、预后判断及指导临床治疗具有十分重要的意义。
OBJECTIVE: To detect the expression of c-met and HER-2 in breast cancer and to analyze the correlation between c-met and HER-2 expression and the correlation between c-met and HER-2 expression and clinical pathology and related molecular biology . Methods: The clinical and pathological data of 106 patients with breast cancer were retrospectively analyzed. The expression of c-met and HER-2 gene were detected by immunohistochemical staining. The expression of c- Met and HER-2 expression and its correlation with clinicopathological parameters. Results: The positive rates of c-met expression in 64 cases of breast cancer were 64.15% (68/106), 50.94% (54/106) in HER-2, 59.43% (63/106) in ER, (53/106). The expression of HER-2 was correlated with axillary lymph node metastasis (P = 0.001) and clinical stage (P <0.001) in breast cancer patients. The expression of c-met gene was correlated with the axillary lymph node metastasis (P = 0.004) P = 0.001). There was no significant difference between the two expressions and the tumor diameter and the expression of ER and PR. There was no correlation between HER-2 and c-met expression, r = 0.071, P = 0.172. Conclusion: The combined detection of c-met and HER-2 gene is of great significance for lymph node metastasis, prognosis and clinical treatment in breast cancer.