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本文报告了作者们自1959～1978年所见到的17例WG患者,包括男7人,女10人,年龄在 20～60岁之间。文章分析了患者的临床症状和治疗效果。除3例系死亡后确诊者外,其余14例都采用了细胞毒药物治疗,持续时间从5～158个月不等,12例用6-巯基嘌呤(6-MP),开始时用量100～150mg/日,维持量50mg/日。其余1例用环磷酰胺;另1例先用硫唑嘌呤(Azathioprine,义美仁),后改用环磷酰胺。在应用细胞毒药物治疗时,几乎所有病例都给予大剂量强的松,俟病情控制后逐渐减少至维持量15～30mg/日,在6～12个月后设法撤去类固醇,但多数病例由于再发而未成功,有5例只偶而接受小量类固醇。
This article reports 17 patients with WG who were seen by the authors from 1959 to 1978, including 7 males and 10 females, aged 20 to 60 years. The article analyzes the patient’s clinical symptoms and treatment. Except for 3 cases diagnosed after death, the remaining 14 cases were treated with cytotoxic drugs for a duration ranging from 5 to 158 months, with 6-mercaptopurine (6-MP) in 12 cases and the initial dosage of 100 ~ 150mg / day, maintenance dose 50mg / day. The remaining 1 case with cyclophosphamide; another case of first with azathioprine (Azathioprine, Yimei), after the switch to cyclophosphamide. In the application of cytotoxic drug treatment, almost all cases were given large doses of prednisone, 俟 disease control gradually reduced to maintain the amount of 15 ~ 30mg / day, after 6 to 12 months to try to remove steroids, but in most cases due to Fat did not succeed, 5 cases occasionally receive small amounts of steroids.