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近年来,推荐血管紧张素转化酶抑制剂治疗成人心力衰竭(以下简称心衰)是一个重要的进步。巯甲丙脯酸(Captopril)和Enalapril广泛地应用于成人高血压和心衰的治疗,在婴儿心衰治疗中应用Captopril仅有2例报告,而用Enalapri1尚无报告。本文报告8例以利尿剂治疗无效的严重心衰婴儿用Enalapril治疗的经验。病人和方法利尿剂治疗无效和不可能作矫形手术的8例有严重心衰的婴儿接受Enalapril治疗。开始治疗年龄为4天～12周(平均3周)其中患室间隔缺损2例、室间隔缺损并多种畸形4例、主动脉缩窄1例、心肌炎1例。临床上表现呼吸频率增快,皮肤花斑、出汗、肝大、奔马律。Enalapril治疗前24小时
In recent years, recommended angiotensin-converting enzyme inhibitors for the treatment of adult heart failure (hereinafter referred to as heart failure) is an important step forward. Captopril and Enalapril are widely used in the treatment of hypertension and heart failure in adults. Only two cases of Captopril have been reported in the treatment of infantile heart failure, and no report has been made with Enalapri1. This article reports the experience of 8 patients treated with Enalapril in 8 infants with severe CHF who are refractory to diuretic therapy. Patients and Methods Eight infants with severe heart failure who were ineffective and unlikely to undergo orthopedic treatment received Enalapril. Beginning treatment for the age of 4 days to 12 weeks (average 3 weeks), including ventricular septal defect in 2 cases, ventricular septal defect and a variety of deformities in 4 cases, 1 case of aortic stenosis, myocarditis in 1 case. Clinical manifestations of respiratory rate increased, skin, sweat, liver, gallop. 24 hours before Enalapril treatment