骨肿瘤治疗的疗效主要依靠早期正确的诊断,在提倡综合治疗、保肢术日趋普及的今天,对恶性骨肿瘤来说早诊断尤为重要。其血行转移的发生率高且早,进展迅速,早期诊断及治疗较为困难。肿瘤标志物在骨肿瘤组织中的表达及其与肿瘤恶性程度的关系可以较好的应用在临床,为早诊断提供依据。现将国内外的这方面的进展综述如下。 The efficacy of bone tumor treatment depends mainly on the correct early diagnosis, in promoting the comprehensive treatment of limb salvage surgery is increasingly popular today, early diagnosis of malignant bone tumors is particularly important. The incidence of hematogenous metastasis is high and early, rapid progress, early diagnosis and treatment more difficult. The expression of tumor markers in bone tumor tissue and its relationship with the degree of tumor malignancy can be better applied in clinical, provide the basis for early diagnosis. The progress in this area both at home and abroad is summarized as follows.