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本文系观察合成前列腺素E即misoprotol是否能预防非类固醇性抗炎药引起胃溃疡的双盲对照研究. 420例被研究的病人患有骨关节炎且并发有非类固醇抗炎药所致的腹痛,曾服用布洛芬、piroxicam和萘普生.将这些病人分为两组(治疗组和对照组)、治序组用misoprostol100ug或200ug,对照组用安慰剂,每天服药四次,即在进餐时及睡眠前服.同时均继续服非类固醇性抗炎药.在开始试验时,以及连续服用misoprostol或安慰剂1月、2月及3月分别作胃镜检查。患者腹痛由本人
This is a double-blind, controlled, observational study of whether synthetic prostaglandin E, or misoprotol, prevents non-steroidal anti-inflammatory drugs from causing gastric ulcers.420 of the studied patients with osteoarthritis and concurrent non-steroidal anti-inflammatory drug-induced abdominal pain , Who took ibuprofen, piroxicam, and naproxen.They were divided into two groups (treatment group and control group), the control group with misoprostol 100ug or 200ug, the control group with placebo, taking medicine four times a day, that is, eating And before going to sleep.At the same time continue to take non-steroidal anti-inflammatory drugs.At the beginning of the trial, and continuous taking of misoprostol or placebo in January, February and March for gastroscopy respectively. Abdominal pain by the patient himself