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目的:了解重组人促红细胞生成素对早产儿脑和神经行为发育的影响。方法:将56例早产儿随机纳入促红细胞生成素治疗组和对照组各28例,治疗组于出生第1周即给rHu-EPO750U.kg-1.w-1,隔日1次,每周3次,共6周,两组均给予维生素K1及补充水、电解质和能量等治疗。矫正胎(年)龄40周、3个月、12个月时两组早产儿均分别进行新生儿行为神经测定(NBNA评分)和神经系统发育评估(婴幼儿智能发育量表)。结果:矫正胎龄40周时,治疗组早产儿行为神经测定得分(39.14±0.51),明显高于对照组(35.10±0.97)(P<0.05);矫正年龄3个月、12个月时,智力发育指数和心理运动发育指数治疗组明显高于对照组(P<0.05)。结论:重组人促红细胞生成素对早产儿脑和神经行为发育可能有促进作用。
Objective: To investigate the effect of recombinant human erythropoietin on brain and neurobehavioral development in preterm infants. Methods: Fifty-six preterm infants were randomly divided into two groups: treatment group (n = 28) and control group (n = 28). The treatment group received rHu-EPO750U.kg-1.w- A total of 6 weeks, both groups were given vitamin K1 and water, electrolytes and energy treatment. Neonatal behavioral neurological assessment (NBNA score) and neurological development assessment (intelligent developmental scale for infants and young children) were performed on the two groups of preterm infants at 40 weeks, 3 months and 12 months after correction. Results: After correction of gestational age, the score of behavioral nerve in preterm infants in treatment group (39.14 ± 0.51) was significantly higher than that in control group (35.10 ± 0.97) (P <0.05) at 40 weeks of gestation. At the corrected age of 3 months and 12 months, Mental development index and psychomotor development index were significantly higher in the treatment group than in the control group (P <0.05). Conclusion: Recombinant human erythropoietin may promote brain and neurobehavioral development in preterm infants.