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目的:探讨环丙沙星致过敏性休克的特点及相关因素,为临床安全用药提供参考。方法:利用“中文期刊全文数据库”、“中文科技期刊全文数据库”和“万方数据医药信息镜像系统”,对1979年1月至2005年12月发表的文献进行全面检索,检索到环丙沙星致过敏性休克相关文献73篇,患者共81例。对81例患者用药情况进行分类统计和分析总结。结果:81例患者中男性42例(52.5%),女性38例(47.5%),1例性别不详;静脉滴注62例(76.5%),口服19例(23.5%);治愈78例(96.3%),死亡3例(3.7%)。用药后出现休克症状的时间最短为静脉滴注10s左右,最长为连续用药第5天静脉滴注60min左右。有药物过敏史者24例,其中对青霉素过敏者16例;既往无药物过敏史者25例;用药前未询问有无过敏史者32例。1995至2005年每年均有环丙沙星致过敏性休克病例报道,发生地区几乎遍及全国。结论:临床应高度重视环丙沙星引起过敏性休克的严重不良反应,以确保用药安全。
Objective: To investigate the characteristics and related factors of ciprofloxacin-induced anaphylactic shock and provide references for clinical safety. Methods: The articles published from January 1979 to December 2005 were searched comprehensively using “Chinese Journal Full-text Database”, “Chinese Sci-tech Periodicals Full-text Database” and “Wanfang Data Medical Information Mirroring System”. Ciprofloxacin Star induced allergic shock related literature 73 articles, a total of 81 patients. 81 cases of patients were classified statistics and analysis of the situation. Results: Among the 81 patients, 42 (52.5%) were male and 38 (47.5%) were female. One patient was sexually unknown; 62 (76.5%) were intravenously dripped and 19 (23.5%) were oral; 78 %), 3 patients died (3.7%). Shock symptoms after the shortest time for intravenous infusion of about 10s, the longest continuous infusion of drugs on the 5th day of about 60min. There are 24 cases of drug allergy history, of which 16 cases of allergy to penicillin; past no history of drug allergy in 25 cases; medication before asking whether there is a history of allergy in 32 cases. An annual report of ciprofloxacin-induced anaphylactic shock was reported from 1995 to 2005 in almost all areas of the country. Conclusion: Clinical should attach great importance to serious side effects of ciprofloxacin-induced anaphylactic shock to ensure drug safety.