从阿司匹林治疗类风湿性关节炎的病例报告和对健康志愿者的非对照研究表明,大剂量阿司匹林(3.7 10g/天口服或2-20g/天静脉注射)能抑制血浆维生素K依赖性凝血因子水平,使凝血酶原时间延长。目前,关于大剂量口服阿司匹林(约1.3g/天)的临床试验已证明具有抗血栓形成作用。然而,至今尚无大剂量阿司匹林对凝血系统作用的对照研究。本文是一项双盲、安慰剂对照的交叉研究。作者评价了14名健康志愿者(男女各7例,年龄22-37岁)口服阿司匹林(20mg/kg/天)8天,对凝血酶原时间、部分促凝血酶原激酶时间及血浆维生素K依赖性因子Ⅱ、Ⅶ、Ⅸ、Ⅹ、蛋白C和因子V(非维生素K依赖性凝血因子)水平的影响。于第1天(服药前)、第2、4、6、8和10天(停药后2天),用两种不同的生物学方 Case reports from aspirin for rheumatoid arthritis and uncontrolled studies in healthy volunteers showed that high-dose aspirin (3.7 10 g / day orally or 2-20 g / day iv) inhibited plasma vitamin K-dependent coagulation factor levels Prothrombin time. Currently, clinical trials on high-dose oral aspirin (about 1.3 g / day) have demonstrated antithrombotic effects. However, there is no controlled study of the effect of high-dose aspirin on the coagulation system. This article is a double-blind, placebo-controlled cross-over study. The authors evaluated the effects of prothrombin time, partial thromboplastin time, and plasma vitamin K on 14 healthy volunteers (7 males and 7 females, aged 22-37 years) taking aspirin orally (20 mg / kg / day) for 8 days Effects of Factor II, VII, IX, X, Protein C and Factor V (non-vitamin K-dependent coagulation factors) levels. On day 1 (pre-dose), days 2, 4, 6, 8 and 10 (2 days after discontinuation), two different biological protocols