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很多磺胺类药物及青霉素的各种毒性反应曾经记述,但对称性坏疽则极罕见。 12岁男孩于入院前二周因中耳炎,给予磺胺二甲基嘧啶治疗(第一次量2克,以后七天每次量1克Q.4h.),在用药第七天发生无痛性血尿,改用青霉素。4天后耳鼻指趾等的末端,发生紫绀且渐恶化,当即停用青霉素。入院治疗时检查,所有指端出现初期坯死,趾端亦有较轻度之病变,手指及耳鼻等均紫蘭及发凉,患者有肉眼可见之血尿,尿内有蛋白,红血球,及颗粒管型。血液尿素量60毫克/1100毫升,其他体格及化验检查均无异常所见,入院后曾首先静脉
A variety of sulfonamides and penicillin toxicity has been described, but symmetrical gangrene is extremely rare. The 12-year-old boy was given sulfamethazine 2 weeks before admission due to otitis media (first dose of 2 grams, 1 gram Q.4h after seven days), painless hematuria occurred on the seventh day of medication, Switch to penicillin. 4 days after the end of the ear and nose toe, cyanosis and progressive deterioration, immediately disable penicillin. Admission treatment when the check, all the finger end of the initial blanching, toe also have mild lesions, finger and ear, nose and other are purple and cool, patients with visible hematuria, urine protein, red blood cells, and pellets type. Blood urea volume 60 mg / 1100 ml, no other physical and laboratory examination showed abnormalities, after admission had first venous