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目的:探讨猫抓病(CSD)的病原学、流行病学、临床病理特征、诊断和治疗。方法:结合文献复习,报告1例CSD患者的临床资料。结果:汉氏巴尔通体(Bartonellahenselae)是CSD的主要病原体;CSD患者有动物接触史(常为猫或狗);均有自限性局部淋巴结肿大,可有发热;病理特点是淋巴结内坏死性肉芽样微脓肿形成;WarthinStarry染色和BrownHopp染色可见革兰阴性、嗜银性、多形性杆菌。结论:CSD是一种自限性细菌性传染病,其临床特点、淋巴结活体组织检查和特殊染色有助于确诊;治疗以庆大霉素、利福平、环丙氟哌酸、克拉霉素、复方新诺明和阿奇霉素效果较好,必要时也可手术切除肿大的淋巴结。
Objective: To investigate the etiology, epidemiology, clinicopathological features, diagnosis and treatment of cat scratch disease (CSD). Methods: According to the literature review, the clinical data of one case of CSD were reported. Results: Bartonella henselae was the main pathogen of CSD. CSD patients had history of animal exposure (often cats or dogs); both had self-limited local lymph nodes and had fever; pathological features were intra-lymph node necrosis Granulomatous micro abscess formation; WarthinStarry staining and BrownHopp staining can be seen Gram-negative, argentophilic, pleomorphic bacteria. CONCLUSIONS: CSD is a self-limiting bacterial infection and its clinical features, lymph node biopsy and special stainings are helpful for the diagnosis. Treatment with gentamicin, rifampicin, ciprofloxacin, clarithromycin , Cotrimoxazole and azithromycin better effect, if necessary, surgery can also remove the enlarged lymph nodes.