【摘 要】
：
In our efforts for cloning novel I2-superfamily conotoxins using the signal peptide sequence,we identified a novel eonotoxin Lt12.4 from Conus iitteratus.This g
【机 构】
：
Beijing Institute of Biotechnology,Beijing 100071,China
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In our efforts for cloning novel I2-superfamily conotoxins using the signal peptide sequence,we identified a novel eonotoxin Lt12.4 from Conus iitteratus.This gene has a fra mework Ⅻ(-C-C-C-C-CC-C-C-),which is distinct from the cysteine patt I2-superfamily conotoxin(-C-C-CC CC-C-C-).Subsequently,we found the signal peptide sequence of Lt12.4 by 5’-RACE.Using this new sequence,we identified another five novel conotoxins with this cysteine patt from four Conus species(Conus ebeus,Conus imperialis,Conus marmoreus,and C.litteratus).These novel conotoxins have the same cysteine patt as the reported Gla-TxX and Gla-MII,and may contain Gla residues.Furthermore,they have the highly conserved signal peptide and hypervariable mature peptide sequences,and widely exist in Conus species.Therefore,it could be defined as a new superfamily of E-conotoxins.
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