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目的探讨血小板在慢性肝病肝纤维化时的功能变化。方法血小板分析仪检测血小板参数PLT、MPV、PDW,ELISA法检测GMPl40的变化,放免法测定肝纤指标HA、FN、IV-C。结果慢性肝病肝纤维患者血小板参数和肝纤指标均有不同程度变化。结论血小板参与肝纤维化,血小板三项参数的检测可以作为慢性肝病肝纤维化的补充指标。
Objective To investigate the functional changes of platelets during liver fibrosis in chronic liver disease. Methods PLT, MPV and PDW were detected by platelet analyzer. The changes of GMP140 were detected by ELISA and the liver fibrosis indexes HA, FN and IV-C were determined by radioimmunoassay. Results In patients with chronic liver disease, platelet parameters and liver fibrosis indexes varied in varying degrees. Conclusion Platelet is involved in liver fibrosis. The detection of three parameters of platelet can be used as a supplementary indicator of liver fibrosis in chronic liver disease.