口服利尿药是应用最广泛的一类药物。使用利尿药有助于降低高血压的致残率和死亡率,从而有力地防止了脑卒中和充血性心衰的发生。但是在很多临床试验中,利尿药对冠心病未带来有利的影响。它至少部份归固于利尿药治疗中出现的副作用,即对肾脏产生的药理作用。高血压与进行性肾功能障碍的关系仍有争论。治疗急进型高血压可使肾功能明显改 Oral diuretics are the most widely used class of drugs. The use of diuretics helps to reduce the morbidity and mortality of high blood pressure, thus effectively preventing the occurrence of stroke and congestive heart failure. However, in many clinical trials, diuretics on coronary heart disease did not bring a favorable impact. It is due at least in part to the side effects of diuretic treatment, the pharmacological effects on the kidneys. The relationship between hypertension and progressive renal dysfunction remains controversial. Hypertensive treatment of radical renal function can be significantly changed