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给恒河猴右侧颈内动脉注射神经毒药物甲基-苯基-四氢吡啶(MPTP)后,产生右侧黑质神经元脱失,黑质纹状体多巴胺(DA)浓度明显降低,以及左侧帕金森样症状。投予抗帕金森病(PD)药物治疗显著地改善帕金森样症状。采用单光子发射计算机断层扫描(SPECT),以~(99m)Tc-ECD作为显象剂显示偏侧PD猴模型的脑血流灌注,发现猴模型建立3个月内的损毁侧脑的脑血流灌注明显减低,8个月时的损毁侧脑的脑血流灌注转为正常。结果表明脑血流灌注的变化反映了PD的病理生理变化过程。
After injection of the neurotoxic drug methyl-phenyl-tetrahydropyridine (MPTP) into the right internal carotid artery of Rhesus macaques, the denervated nigral neurons of the right side were produced and the concentration of dopamine (DA) in the nigrostriatal striatum was significantly reduced. As well as left-sided Parkinson’s-like symptoms. Parkinson’s disease-like symptoms were significantly improved by administering anti-Parkinson’s disease (PD) medications. Single-photon emission computed tomography (SPECT) was used to show cerebral blood perfusion in hemiparkinsonian monkey models using ~ (99m) Tc-ECD as imaging agent. Flow perfusion was significantly reduced, and cerebral blood flow perfusion at the damaged side of the brain became normal at 8 months. The results show that changes in cerebral blood flow reflect the pathophysiological changes of PD.