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目的探讨类风湿性关节炎(RA)患者血清中基质金属蛋白酶-9(MMP-9)的水平,分析MMP-9与RF、IL-17、TNF-α的相关性,为临床诊断和治疗类风湿性关节炎提供新的理论依据。方法选取65例RA患者其中35例RF阳性,30例RF阴性,另选取RF阳性患者为疾病对照组,从体检中心选取年龄和性别匹配人群为正常对照组,采用酶联免疫吸附试验法检测MMP-9、TNF-α、IL-17含量,特定蛋白仪检测RF含量。结果 RF阳性RA患者血清中MMP-9与TNF-α、IL-17均明显高于其他各组,差异有统计学意义(P<0.05);MMP-9与RF、TNF-α、IL-17呈现明显的相关性(P<0.05),与TNF-α和IL-17无相关性(P>0.05)。结论联合检测将为类风湿性关节炎的诊断和治疗提供更好的辅助依据。
Objective To investigate the serum levels of matrix metalloproteinase-9 (MMP-9) in patients with rheumatoid arthritis (RA) and to analyze the correlation between MMP-9 and RF, IL-17 and TNF-α in clinical diagnosis and treatment Rheumatoid arthritis provides a new theoretical basis. Methods 65 cases of RA patients were 35 cases of RF-positive, RF-negative in 30 cases, the other RF-positive patients selected as the disease control group, selected from the physical examination center of age and gender matched population as the normal control group, enzyme-linked immunosorbent assay MMP -9, TNF-α, IL-17 content, specific protein analyzer to detect RF content. Results The serum levels of MMP-9, TNF-α and IL-17 in patients with RF-positive RA were significantly higher than those in other groups (P <0.05) (P <0.05), but no correlation with TNF-α and IL-17 (P> 0.05). Conclusion Combined detection will provide a better basis for the diagnosis and treatment of rheumatoid arthritis.