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目的探讨血清线粒体天门冬氨酸氨基转移酶同工酶(mitochondrial aspartate aminotransferase,m-AST)在不同肝病患者中的变化及其临床意义。方法用日立7170A全自动生化分析仪测定123例不同肝病患者血清m-AST及ALT、AST、AKP、GGT、AFU、5’-NT活性,对结果进行多变量方差分析。结果各组肝病患者m-AST因病情不同而有不同程度的升高。急性肝炎组m-AST明显升高,与正常对照组相比差异具有显著性(P<0.01),肝硬化代偿期,m-AST变化不明显,失代偿期,m-AST持续升高。AST和ALT两种酶在各种肝病时有不同程度升高。AKP、GGT、5’-NT活力主要在肝癌中增高明显。结论m-AST可作为诊断肝脏损伤、坏死及预后判断的敏感指标,特别是在急性肝炎-慢性肝炎-肝硬化-肝癌这条疾病链上能够比较客观地反映疾病所处时期,作为疾病鉴别诊断、指导治疗及预后判断的一项有价值的指标。
Objective To investigate the changes of serum mitochondrial aspartate aminotransferase (m-AST) in patients with different liver diseases and its clinical significance. Methods The serum m-AST, ALT, AST, AKP, GGT, AFU and 5’-NT activity in 123 patients with different liver diseases were measured by Hitachi 7170A automatic biochemical analyzer. Multivariate analysis of variance was performed on the results. Results The m-AST in patients with liver disease in each group had different degrees of elevation due to different conditions. The level of m-AST in acute hepatitis group was significantly higher than that in normal control group (P <0.01), the compensatory period of liver cirrhosis, the change of m-AST was not obvious, the decompensation period and m-AST level continued to increase . AST and ALT enzymes in a variety of liver disease increased to varying degrees. AKP, GGT, 5’-NT activity mainly increased significantly in liver cancer. Conclusion m-AST can be used as a sensitive indicator in diagnosis of liver injury, necrosis and prognosis, especially in acute hepatitis-chronic hepatitis-liver cirrhosis-liver cancer. The m-AST can objectively reflect the period of the disease, as a differential diagnosis , Guide the treatment and prognosis of a valuable indicator.