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目的探讨复发性卵巢上皮癌再次肿瘤细胞减灭术的预后因素及病例选择标准。方法采用系统评价的方法,收集国内外2003年1月至2007年12月公开发表的二次手术治疗复发性卵巢癌的临床资料,进行分析。制定严格的纳入和排除标准。将可能影响再次肿瘤细胞减灭术中位生存期的预后因素进行定性评价。结果 12篇文献符合纳入标准。具有统计学意义的预后因素包括复发灶的多少、无疾病进展期(DFI)长短、初次手术残余灶大小、最大复发灶的直径,腹水的有无,再次手术残余灶大小。结论满足良好预后的因素为:(1)孤立的复发灶。(2)DFI≥12个月。(3)初次手术时达到理想的肿瘤细胞减灭术。(4)复发时腹水≤500mL。(5)进行了理想的再次肿瘤细胞减灭术。
Objective To investigate the prognostic factors and case selection criteria for recurrent epithelial ovarian cancer recurrence. Methods A systematic review was conducted to collect the clinical data of secondary surgical treatment of recurrent ovarian cancer published from January 2003 to December 2007 both at home and abroad. Develop strict inclusion and exclusion criteria. The prognostic factors that may affect the median survival of tumor cytoreductive surgery again were qualitatively evaluated. Results 12 articles met the inclusion criteria. The statistically significant prognostic factors included the number of recurrences, the duration of no disease progression (DFI), the size of the initial surgical residual tumor, the maximum recurrence diameter, the presence of ascites, and the size of the residual surgical re-operation. Conclusions The factors that satisfy the good prognosis are: (1) isolated recurrent foci. (2) DFI ≥12 months. (3) achieve the ideal tumor cytoreductive surgery at the time of the first operation. (4) recurrent ascites ≤ 500mL. (5) An ideal second cytoreductive surgery was performed.