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T2DM等代谢性疾病的患病率逐年上升且出现发病年轻化的趋势,已成为现代社会人类健康的主要威胁,其发病机制之一是机体外周组织,特别是骨骼肌组织摄取葡萄糖功能受损引起的骨骼肌IR。最新研究显示,组蛋白去乙酰化酶(HDAC)在骨骼肌细胞代谢相关基因转录调控机制中发挥着重要作用,可为治疗代谢性疾病提供潜在药物作用靶点。
The prevalence of T2DM and other metabolic diseases is increasing year by year and the incidence of rejuvenation tends to become a major threat to human health in modern society. One of the pathogenesis of this disease is the damage caused by the impaired glucose uptake in peripheral tissues, especially skeletal muscle tissue Skeletal muscle IR. Recent studies show that histone deacetylases (HDACs) play an important role in the transcriptional regulation of skeletal muscle cell metabolism-related genes and may provide potential drug targets for the treatment of metabolic diseases.