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脂质体灭菌仍是制剂中的一个问题。在无菌条件下生产是可能的，但较复杂且耗费大。要求灭菌工艺对脂质体的粒度及化学组成设有影响且所包裹药物不致漏出。符合上述要求的灭菌方法有二种，一是经孔径0．2g灿的微孔膜过滤，二是冻干脂质体暴露于环氧乙烷。但过滤法不能用于较大脂
Liposome sterilization is still a problem in the formulation. Production under aseptic conditions is possible but complicated and costly. The sterilization process is required to have an effect on the particle size and chemical composition of the liposomes and the encapsulated drug will not leak out. In line with the above requirements there are two sterilization methods, one is through the pore size of 0.2g Can microporous membrane filtration, the second is freeze-dried liposomes exposed to ethylene oxide. But filtration can not be used for larger fat