目的:总结颈椎节细胞神经瘤的临床特点,探讨其手术治疗效果。方法:2001年6月～2007年7月我院手术治疗颈椎节细胞神经瘤患者10例,男5例,女5例,年龄28～65岁,平均45.1岁。6例以根性疼痛为主要表现,4例以肿瘤压迫平面以下肌力下降为主要表现,3例患者有与肿瘤所在水平相关的感觉障碍平面。MRI检查显示肿瘤在T1WI呈低信号、T2WI呈高信号,增强后有强化;在轴位像上肿瘤位于髓外-硬膜内外者3例,其中2例沿椎间孔呈哑铃形生长,7例肿瘤位于硬脊膜外-椎间孔内外呈哑铃形;C1～C2水平者4例,C3～C41例,C4～C51例,C5～C63例,C4～C61例。2例肿瘤主体位于髓外-硬膜下者采用常规双侧椎板切除显露,8例肿瘤主体位于椎间孔者采用患侧半椎板-小关节突切除显露,于显微镜下行肿瘤分离切除。2例哑铃形肿瘤椎管外部分较大,附加后外侧入路切除椎旁部分。结果:肿瘤全切除9例,次全切除1例。术后病理检查可见成熟或未成熟的肿瘤性节细胞散在或成束穿插于肿瘤性雪旺氏细胞间质中,肿瘤中可见正常的神经纤维呈束状排列。术后发生脑脊液漏2例,经对症处理后治愈。术前6例神经根痛患者,术后4例症状缓解或消失,2例无变化。术前4例上、下肢运动障碍者,术后3例改善,1例无变化。随访2.1～7.2年,平均4.1年,末次随访时脊髓功能状态按McCormick分级标准评价,好转8例,不变2例。随访期间1例次全切除患者术后2年肿瘤原位硬膜下复发,再次手术切除,另9例无复发。结论:颈椎节细胞神经瘤临床上以根性疼痛及感觉运动障碍为主要表现,肿瘤形态大多数为骑跨椎间孔呈哑铃形生长,肿瘤主体多位于硬膜外。手术全切除后预后良好。 OBJECTIVE: To summarize the clinical features of cervical ganglioneuroma and to investigate the surgical treatment effect. Methods: From June 2001 to July 2007, 10 cases of cervical ganglioneurocytoma were treated in our hospital. There were 5 males and 5 females, aged 28-65 years, with an average age of 45.1 years. Of the 6 patients, radical pain was the major manifestation. Four patients showed decreased muscle strength under the tumor compression plane, and three patients had a level of sensory disturbance related to the level of the tumor. MRI showed low signal on T1WI, high signal on T2WI and enhanced enhancement. In axial image, the tumor was located in extramedullary - extradural and intrauterine in 3 cases, of which 2 cases dumbbell-shaped growth along the intervertebral foramen, 7 Cases of tumor located in the epidural - foramen inside and outside the dumbbell shape; C1 ~ C2 level in 4 cases, C3 ~ C41 cases, C4 ~ C51 cases, C5 ~ C63 cases, C4 ~ C61 cases. Two cases of tumor located in the extramedullary - subdural were revealed by conventional bilateral laminectomy. Eight of the tumors located in the intervertebral foramina were resected by resection of the iliotithrombosis in the affected side and removed by microscopy. Two cases of dumbbell tumors outside the larger part of the spinal canal, additional lateral paravertebral resection. Results: Total resection in 9 cases, subtotal resection in 1 case. Postoperative pathological examination showed mature or immature tumor nodular interspersed interspersed interspersed or bundled in the tumor of Schwann cell, the tumor can be seen in normal nerve fibers arranged in a bundle. Postoperative cerebrospinal fluid leakage in 2 cases, cured by symptomatic treatment. Preoperative 6 patients with radicular pain, postoperative symptoms of 4 patients relieved or disappeared, 2 patients without change. In the 4 cases before and after the operation, the patients with lower extremity dyskinesia were improved in 3 cases and no change in 1 case. The follow-up ranged from 2.1 to 7.2 years, with an average of 4.1 years. The functional status of the spinal cord at the last follow-up was evaluated according to the McCormick grading scale, with 8 cases being improved and 2 cases unchanged. During subtotal follow-up, one case of subtotal resection was followed up for subdural tumor in situ 2 years after operation, resected again and the other 9 cases had no recurrence. CONCLUSION: Cervical ganglioneuroma is mainly characterized by radicular pain and sensory dyskinesia. Most of the tumors form dumbbell-shaped growth in the intervertebral foramen. Most of the tumors are located in the epidural space. After the total excision of the prognosis is good.