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病毒作为人类多种疾病的病原体之一,具有非常复杂的感染和繁殖机制,尤其是人类免疫缺陷病毒(HIV)和肝炎病毒(HBV/HCV),至今没有彻底清除的方法,严重影响患者的生命健康和生存质量。对病毒发病机理的研究是攻克抗病毒药物研究难题及改善抗病毒治疗的关键。数学模型作为促进人们理解病毒产生、复制和消除的重要工具,如今已广泛应用于抗病毒药物研究和病毒发病机理研究。本文概述了:(1)病毒感染动力学的基本模型及其在人类免疫缺陷病毒(HIV)和肝炎病毒(HBV/HCV)研究中的应用;(2)以基本模型为基础的药物的干预作用模型;(3)病毒靶细胞模型;(4)机体对病毒产生免疫作用的免疫模型;(5)病毒耐药性突变模型等。这些模型可为今后的抗病毒研究提供有价值的参考。
As one of the pathogens of many human diseases, the virus has a very complicated mechanism of infection and reproduction, especially the human immunodeficiency virus (HIV) and hepatitis virus (HBV / HCV). To date, there is no complete elimination method that seriously affects the life of a patient Health and quality of life. Research on the pathogenesis of the virus is the key to overcome the research challenges of antiviral drugs and improve the antiviral treatment. As an important tool to promote understanding of virus production, replication and elimination, mathematical models are now widely used in the research of antiviral drugs and virus pathogenesis. This article summarizes: (1) the basic model of viral infection kinetics and its use in the study of human immunodeficiency virus (HIV) and hepatitis virus (HBV / HCV); (2) the interventional effects of drugs based on the basic model Model; (3) virus target cell model; (4) the immune model of the body to produce the immune effect of the virus; (5) the virus resistance mutation model. These models can provide valuable reference for future antiviral research.