在8例健康志愿者中进行国产与进口环丙沙星片药物动力学与生物利用度的研究.采用随机交叉试验设计单剂量po 500mg环丙沙星片.用HPLC法测定血药浓度,国产与进口两种制剂的各项动力学参数为AUC[(10.49±1.16,10.33±1.31)μg·h/ml],T_1/2β[(5.34±1.84,4.90±0.94)h],CL(s)/F[(48.29±6.11,49.10±5.71)h~(-1)],T_(max)[(1.04±0.38,0.83±0.29)h」,C_(max)[(1.53±0.31,1.86±0.55)μg/ml],Vc/F[(218.8±43.8,184.9±50.9)L],经统计学处理.两者无显著性差异,以进口片为标准求得国产片的生物利用度为102%. The pharmacokinetics and bioavailability of domestic and imported ciprofloxacin tablets in 8 healthy volunteers were studied.A single dose of 500 mg ciprofloxacin tablet was designed by randomized crossover test.HPLC concentrations were determined by HPLC The kinetic parameters of the two preparations were AUC [(10.49 ± 1.16,10.33 ± 1.31) μg · h / ml], T_1 / 2β [(5.34 ± 1.84,4.90 ± 0.94) h], CL /F[(48.29 ± 6.11, 49.10 ± 5.71) h~(-1)],T_(max)[(1.04 ± 0.38,0.83 ± 0.29) hÅbars, C_(max)[(1.53 ± 0.31,1.86 ± 0.55 ) μg / ml] and Vc / F [(218.8 ± 43.8,184.9 ± 50.9) L], respectively, and there was no significant difference between the two. The bioavailability of domestic tablets was 102% .