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目前认为非基因毒致癌物(NGCs)可能以不同的方式起作用。在啮齿动物长期生物测试中,应用高浓度化学物一般足以杀死细胞。新形成细胞所修复的损伤,能起“分裂素”的作用,促进细胞增殖,因而与静止期细胞相比,增加了突变的风险。其它的一些紊乱,如雄性大鼠肾小管中α_2-微球蛋白浓度的增加,大鼠肾肿瘤中钙重吸收功能的破坏,或因过氧物酶体增生的增加而导致啮齿动物肝细胞的有丝分裂,这些异常都可能与NGGs的作用有关。
At present, it is considered that non-genotoxic carcinogens (NGCs) may work in different ways. In rodent long-term biological tests, the application of high concentrations of chemicals is generally sufficient to kill the cells. The damage that is repaired by newly formed cells can act as a “mitogen” and promote cell proliferation, thereby increasing the risk of mutations compared to quiescent cells. Other disorders, such as the increase of α 2 -microglobulin concentration in the renal tubules of male rats, the destruction of calcium reabsorption in rat kidney tumors, or the increase in peroxisomal hyperplasia of rodent hepatocytes Mitosis, these abnormalities may be related to the role of NGGs.