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目的：调查分析龙岗中心医院就诊患者及体检者幽门螺杆菌（HP）感染状况、不同病变HP感染率，分析三联疗法及伴随疗法根除率。方法应用14C呼气试验检测患者及体检者是否感染幽门螺杆菌，对就诊患者行胃镜检查，统计其结果，收集三联疗法及伴随疗法治疗后复查患者资料，统计其根除率。结果9616例初查患者中HP感染率为42．16％，310例体检者HP感染率为35．81％，两者差异有统计学意义（P＜0．05）；性别、年龄、季节之间差异无统计学意义（P＞0．05）；不同病种差异有统计学意义（P＜0．05）；三联疗法根除率为59．19％（264／446），伴随疗法为82．14％（23／28），两者差异有统计学意义（P＜0．05）。结论就诊患者HP感染率高于体检者，不同病变HP感染率有差异，就诊患者HP感染率及根除率均处于国内外较低水平。“,”Objective To investigate and evaluate the Helicobacter pylori(HP) infection status in Longgang District Central Hospital,and compare the differences of infection rate of HP between different kinds of stomach lesions,as well as the differences of the eradication rate of HP between triple therapy and concomitant therapy. Methods HP infection was confirmed by 14C breath test. The upper digestive tract symptoms of patients were detected under the gastroscopy. For those HP infection was confirmed, triple therapy and concomitant therapy were given randomly, and calculated for the eradication rate of HP. Results HP infection rate was 42.16% in 9 616 patients and 35.81% in 310 cases, the difference was statistically significant (P0.05). There were significant differences in HP infection rates between different kind of stomach lesions (P<0.05).The eradication rate of HP of the triple therapy [59.19%(264/446)] was significantly lower than that of concomitant therapy [82.14%(23/28)](P<0.05). Conclusions The HP infection rate of patients was higher than that of the people taking body check, and the infection rates of HP were different in different kinds of stomach lesions.The HP infection rate and eradication rate of HP were lower than those of China and overseas.