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一种可治疗精神分裂症新药为甲基咔唑酮(GR 38032F),属5-羟色胺受体对抗剂(5HT_3),5HT_3受体在调节某些脑区神经细胞活动中起一定作用,并能控制恶心、呕吐和胃的活动.GR 38032F具有高度选择性,不阻断脑多巴胺受体,动物实验表明,该药对人体可能有抗精神病作用.精神分裂症与脑中边叶区多巴胺能活性增强有关,用于控制该病的安定镇痛药可直接阻断多巴胺受体抑制多巴胺的活性.实验在13天内利用渗透微泵将多巴胺注入鼠和狨脑中,用此法给予多巴胺产生一种活性过度综合症,止吐灵、氟奋乃静和GR 38032F均以剂量依赖型方式使其减弱,但剂量增加时,安定镇
One of the new drugs that can treat schizophrenia is methylcarbazolone (GR 38032F), which belongs to the serotonin receptor antagonist (5HT_3). The 5HT_3 receptor plays a role in the regulation of nerve cell activity in some brain regions and can Control nausea, vomiting and stomach activity.GR 38032F highly selective, does not block the brain dopamine receptor, animal experiments show that the drug may have anti-psychotic effect on the human body.Schizophrenia and the brain in the midbrain dopaminergic activity Augmentation, analgesics used to control the disease and diazepam can directly block the dopamine receptor inhibit dopamine activity in the experiment within 13 days using osmotic micro-pump to inject dopamine into the brain and rat brain, this method is given to produce a dopamine Active hypersensitivity syndrome, statin, fluphenazine, and GR 38032F all decreased in a dose-dependent manner, but when the dose was increased,