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用冷热试验研究氨基甙类药物对前庭的毒性作用,首先必须探讨此法的重复性如何。为此作者们对25名(男15,女10;主要为中、青年)正常人进行44℃热水试验和电眼震图描记,以最大慢相速度和最大频率为指标;22例重复试验两次,18例重复试验3次;第1、2次试验间隔时间为24～72小时,第1、3次试验间隔时间为3月。结果发现:最大慢相速度在第2次试验比第1次有反应减退现象,差别显著,18耳减退超过30%;3个月第3次试验仍比第1次反应减弱,差别显著。最大频率在第2次试验比第1次也有反应减退现象,但无显著差异,不过也有3耳减退超过30%;3个月后第3次试验时,平均值虽恢复到
To test the toxic effects of aminoglycosides on the vestibule with the hot and cold test, we must first explore the repeatability of this method. To this end, the authors conducted hot water test at 44 ℃ and electrogram nystagmus on 25 normal men (15 men and 10 women, mainly middle and young adults), taking the maximum slow phase velocity and maximum frequency as indexes. Twenty-two repeat experiments Times, 18 cases repeated test 3 times; first and second test interval of 24 to 72 hours, the first and third test interval of March. The results showed that: the maximum slow phase velocity in the second test than the first reaction decreased phenomenon, significant difference, 18 ears decreased more than 30%; 3 months of the third test was still weaker than the first reaction, the difference was significant. The maximum frequency in the second test than the first reaction also decreased, but no significant difference, but also 3 ears decreased more than 30%; 3 months after the third test, the average was restored to