目的观察MTA和Vitapex糊剂应用于成人慢性根尖周炎所致根尖孔开放的临床疗效。方法对在本院牙体牙髓科就诊的慢性根尖周炎至根尖孔开放的30例患者,随机分为2组,实验组18例施以MTA根尖孔封闭加热牙胶充填术,对照组12例利用Vitapex糊剂诱导根尖部出现钙化组织后进行根管充填。2组于6个月、12个月时进行随访,观察临床疗效及X线片情况。结果治疗6个月时,MTA组与Vitapex糊剂组的有效率分别为94.44%和91.67%,差异无统计学意义(P>0.05)。治疗12月后2组的有效率分别为94.44%和75%,差异有统计学意义(P<0.05)。实验组在治疗后均无临床不适症状。结论 MTA作为根尖封闭材料较Vitapex糊剂而言有着明显的临床优势。 Objective To observe the clinical effect of MTA and Vitapex paste applied to open apical foramen caused by chronic periapical periodontitis in adults. Methods Thirty patients with chronic periapical periodontitis open to the apical foramen in our department were randomly divided into two groups. In the experimental group, 18 cases were treated with MTA apical foramen ovales, In the control group, 12 cases of root canal filled with Vitapex paste were used to induce the calcification of the apical part. 2 groups were followed up at 6 months and 12 months to observe the clinical efficacy and X-ray film. Results At 6 months, the effective rates of MTA group and Vitapex paste group were 94.44% and 91.67%, respectively, with no significant difference (P> 0.05). After 12 months of treatment, the effective rates of the two groups were 94.44% and 75% respectively, with statistical significance (P <0.05). The experimental group had no clinical symptoms after treatment. Conclusions MTA has a clear clinical advantage as a root apical sealant compared to Vitapex paste.