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目的探讨急性冠脉综合征(ACS)患者血尿酸升高的相关危险因素。方法将228例ACS患者按照血尿酸水平分为A组(血尿酸<260.0μmol/L)、B组(血尿酸260.0～305.5μmol/L)、C组(血尿酸305.5～376.5μmol/L)、D组(血尿酸>376.5μmol/L)组,观察各组性别、年龄、高血压史、糖尿病史、吸烟史、左心室的射血分数(LVEF)、血尿素氮(BUN)、血肌酐(Cr)、总胆固醇(CHO)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(BFS),采用Logistic回归分析血尿酸升高的主要因素。结果四组间性别、吸烟史、BUN、Cr、TG和LVEF存在统计学差异,P<0.05;Logistic回归分析显示,BUN、Cr、TG、吸烟史是ACS患者血尿酸升高的危险因素。结论 BUN、Cr、TG水平升高和吸烟可能为ACS患者发生高尿酸血症的重要原因。
Objective To investigate the related risk factors of elevated serum uric acid in patients with acute coronary syndrome (ACS). Methods A total of 228 ACS patients were divided into group A (serum uric acid <260.0μmol / L), group B (serum uric acid 260.0-305.5μmol / L), group C (serum uric acid 305.5-376.5μmol / L) D group (serum uric acid> 376.5μmol / L). The gender, age, history of hypertension, history of diabetes, smoking history, left ventricular ejection fraction (LVEF), blood urea nitrogen (BUN) and serum creatinine Cr, total cholesterol, TG, HDL, LDL and fasting blood glucose (BFS) were determined by Logistic regression analysis. Results There was a significant difference in sex, smoking history, BUN, Cr, TG and LVEF among the four groups (P <0.05). Logistic regression analysis showed that BUN, Cr, TG and smoking history were risk factors of elevated serum uric acid in ACS patients. Conclusions The elevated levels of BUN, Cr, TG and smoking may be the important reasons of hyperuricemia in ACS patients.