利用峰漂移法微乳液电动色谱,评价了相对淌度在药物脂水分配系数(lg Po/w)测定中的应用.使用5种不同疏水性化合物验证了此法的可行性,与采用淌度的测量结果进行了比较;并应用提出的方法测定了3种药物的lg Po/w值,实验值与文献值的平均误差为0.18,准确性好.结果表明,使用相对淌度描述被分析物的迁移行为,有效避免了实验过程中溶液粘度变化、电压、电流以及温度等实验条件的波动引入的误差,提高了lg Po/w测定准确性,为药物疏水性的评价提供一种新的选择. The application of peak-shift microemulsion electrokinetic chromatography to the determination of the relative mobility in the determination of lipid-water partition coefficient (lg Po / w) was evaluated.The five different hydrophobic compounds were used to verify the feasibility of this method, And the proposed method was used to determine the lg Po / w values ​​of the three drugs with an average error of 0.18 between the experimental and literature values ​​of 0.18 and the accuracy was good.The results showed that the relative mobility of the analytes , Which effectively avoids the errors introduced by experimental conditions such as the change of solution viscosity, voltage, current and temperature, and improves the determination accuracy of lg Po / w, providing a new choice for the evaluation of drug hydrophobicity .