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乙酰肝素酶(Hpa)可降解细胞外基质(ECM)和基底膜中的硫酸乙酰肝素,破坏其完整性,同时释放在细胞外基质中储存的碱性成纤维细胞生长因子(b-FGF),促进肿瘤血管的生成,从而有利于肿瘤细胞的侵袭和转移。现探讨Hpa、b-FGF 与肝癌的临床病理特征及肿瘤血管新生之间的关系。
Heparanase (Hpa) degrades heparan sulfate in the extracellular matrix (ECM) and basement membrane and disrupts its integrity, while releasing basic fibroblast growth factor (b-FGF) stored in the extracellular matrix. Promote the formation of tumor blood vessels, which is conducive to tumor cell invasion and metastasis. The relationship between Hpa, b-FGF and the clinicopathological features of liver cancer and tumor angiogenesis are discussed.