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本工作在原代培养的小鼠肝细胞上观察了一氧化氮（NO）、cGMP和CAMP的变化与神经降压素肝细胞保护作用之间的关系。结果如下：向培养液中加入酪氨酚（20mmol／L）12h后，GOT和GPT漏出明显增加；在加醋氢酚之前给予神经降压素（10-7mol／L）则使转氨酶漏出明显减轻。给予NO合成酶阻断剂L－NAME可完全阻断神经降压素的保护作用。神经降压素使肝细胞内cGMP含量显著增加，但对cAMP含量无明显影响。结果表明，神经降压素的肝细胞保护作用是由NO介导的，且与cGMP有一定关系。
This work observed the relationship between changes of nitric oxide (NO), cGMP and CAMP and neurotensin hepatocyte protective effect in primary cultured mouse hepatocytes. The results were as follows: GOT and GPT leakage significantly increased after adding tyrosol (20mmol / L) to the culture medium for 12h; administration of neurotensin (10-7mol / L) before adding hydrobromide reduced the leakage of transaminase significantly . Administration of NO synthase blocker L-NAME completely blocked the neurotensin’s protective effect. Neurotensin significantly increased the content of cGMP in hepatocytes, but had no significant effect on cAMP content. The results showed that neurotensin hepatocyte protective effect is mediated by NO, and has a certain relationship with cGMP.