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感染是白血病患者病势恶化及致死的主要原因,而败血症是可伯的诊断和治疗上的难题。作者研究儿童急性淋巴细胞白血病(ALL)中50例次败血症,以探讨何种细菌是病原菌以及中性粒细胞水平和发生败血症之间比较密切的相互关系。每个病人做白细胞计数及分类,中性粒细胞太低者,要计算粒细胞绝对计数(AGC)。当病人的体温超过38.5℃时,至少采集二次血标本进行需氧和无氧二种方法培养。对所有发热病人最初的治疗包括新青Ⅱ和庆大霉素。当AGC低于1,000/mm~3时,一开始就加羧苄青霉素治疗。血培养阳性者则在敏感试验的基础上选择单一的或协同的联合抗菌素治疗7～10天。75例儿童ALL发生50例次败血症(没有一例进行脾切除或接受过预防性抗菌素)。50
Infection is the main cause of the deterioration and death of patients with leukemia, and sepsis is a problem in the diagnosis and treatment of Cobra. The authors studied 50 cases of acute sepsis in children with acute lymphoblastic leukemia (ALL) to investigate which bacteria are pathogenic bacteria and the close relationship between levels of neutrophil and sepsis. Each patient is counted and classified as white blood cells, neutrophils are too low, to calculate the absolute number of granulocytes (AGC). When the patient’s body temperature exceeds 38.5°C, at least secondary blood samples are collected for aerobic and anaerobic methods. The initial treatment for all fever patients included Xinqing II and gentamicin. When AGC is lower than 1,000/mm~3, carbenicillin treatment is added at the beginning. Those with positive blood cultures chose a single or synergistic combination of antibiotics for 7 to 10 days on the basis of sensitivity tests. Fifty episodes of sepsis occurred in 75 children with ALL (none had splenectomy or received prophylactic antibiotics). 50