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[目的]比较不同剂量米索湿化后阴道置药对宫颈扩张的疗效及副反应,探索简单、有效的置药方法及适宜剂量。[方法]选择孕6～10周未经阴道分娩的妇女180例,随机分为3组,剂量分别为400、200和400μg,于置药后2～2.5h或3～3.5h后手术,比较宫颈扩张程度及副反应情况。[结果]米索放置剂量越大,放置时间越长,宫口扩张效果越好,但腹痛、阴道流血副反应也越严重。[结论]中止6～10周早期妊娠,可选择人工流产术前2～2.5h阴道放置湿化后米索400μg或术前3～3.5h阴道放置湿化后米索200μg;而孕10～12周对象,术前3～3.5h阴道放置湿化后米索400μg较为合理。
[Objective] To compare the curative effect and adverse reactions of vaginal drug delivery after cervical misdiagnosis with different doses of misoprostol to explore the simple and effective drug-setting method and appropriate dosage. [Methods] One hundred and eighty women without vaginal delivery during 6-10 weeks of gestation were randomly divided into 3 groups at doses of 400, 200 and 400 μg, respectively, and were operated at 2 ~ 2.5 h or 3 ~ 3.5 h after drug administration Cervical dilatation and side effects. [Result] The larger the dose of misoprostol was, the longer the placement time was, the better the dilatation effect of cervix was, but the more severe side effects were abdominal pain and vaginal bleeding. [Conclusions] Suspension of 6-10 weeks of early pregnancy can be selected 2 ~ 2.5 h before artificial vaginitis placed vaginal wet 400 g misoprostol or 3 ~ 3.5 h before vaginal wet placement of misoprostol 200μg; pregnant 10 ~ 12 Weekly objects, preoperative 3 ~ 3.5h placed vaginal wet 400g misoprostol more reasonable.